Erectile Dysfunction

Dr.Tim Gianto

Sexual dysfunction

Alprostadil is sold in the United States as urethral suppositories, under the brand name MUSE [3] (Medicated Urethral Suppository for Erection) by Vivus. It is also sold in injectable form as Caverject and Edex.
Muse delivers alprostadil as a penile suppository, inserted into the urethra, at least ten minutes before the erection will be needed. Caverject and Edex are similarly fast-acting, but are actually injected directly into the corpus cavernosum of the penis.

NexMed is developing transdermal formulations—Alprox-TD(R) for men with erectile dysfunction and Femprox(R) for female sexual arousal disorder. Alprox-TD(R) has been selling in China and in Hong Kong since October 2001 and April 2002, respectively. Two Phase III studies have been completed for this product, and the Company is seeking regulatory approval in the U.S., Canada and Europe. [4]
It is also available as a generic. The major cost is that it must be mixed by a compounding pharmacy and the alprostadil is sometimes difficult to get. There are different formulations (bi-mix, trimix) which may include papaverine and/or phentolamine. A sample mix might be papaverine 30 mg, phentolamine 2 mg, & alprostadil 20 mcg
As a generic, it is much less expensive than the pre-packaged injectables. For one thing, it is premixed (must be kept refrigerated) so one only loads the syringe with the quantity needed.
[edit] Other uses
Alprostadil is also used in maintaining a patent ductus arteriosus in the newborn. This is primarily useful when there is threat of premature closure of the ductus arteriosus in an infant with ductal-dependent congenital heart disease, including cyanotic lesions (e.g., pulmonary atresia/stenosis, tricuspid atresia/stenosis, transposition of the great arteries) and acyanotic lesions (e.g., coarctation of the aorta, hypoplastic left heart syndrome, critical aortic stenosis, interrupted aortic arc
Methods and compositions for misoprostol compound treatment of erectile dysfunction
United States Patent 6589990
Ads by Google
Blizzard the Ferret
Blizzard Memorial Fund To Assist Ferret Shelters in the US
ferretlover97.terrabox.com
Therapeutic formulations and methods for treating erectile dysfunction with a misoprostol compound in a subject are provided, a method comprising: obtaining a therapeutic formulation having an effective dose of a misoprostol compound in an excipient carrier; and applying the therapeutic formulation topically to the subject.


Erectile dysfunction
A 1998 study found misoprostol to be helpful as a supplement to a vacuum pump (VED) in the treatment of erectile dysfunction, but not effective by itself.[22] The paper concluded "The intraurethral application of misoprostol significantly improves the quality of VED-induced erections. This agent seems to be a cheap intraurethral adjunct to VED with mild to moderate local side-effects".


In my own experiment,misoprostol injected into the corpus cavernosum,definitely helps patients with E.D. with minor side effect.